Clinical Publications

Alzheimer's Research.

Accelerating the path to reversal through clinical genomics and system-level intervention planning. Validated by 9 accepted papers in 2026.

9 Accepted Alzheimer Papers 2 Oral Presentations 5 Major Venues Genomics & Foundation Models, 2026

Live Presentations

Presenting at AAAI-26 · Singapore

David Scott Lewis presenting our Alzheimer's AI research at the AAAI 2026 conference — Singapore Expo.

David Scott Lewis presenting Neuro-Symbolic AI for Alzheimer's Disease at AAAI-26 Singapore Expo — **ORAL · AAAI-26 LMReasoning Workshop**
"Neuro-Symbolic AI for Alzheimer's Disease" — Physics-Informed Biomarker Prediction & Verifiable Intervention Planning

David Scott Lewis presenting the Cell Reports Medicine foundational Alzheimer's reversal paper at AAAI-26 — **Cell Reports Medicine · January 2026**
"Pharmacologic Reversal of Advanced Alzheimer's Disease in Mice" — the foundational paper powering our platform

Breakthrough Paper

The Foundational Discovery

The peer-reviewed breakthrough that inspired The Reversal Initiative — demonstrating the potential for pathology reversal in vivo.

Cell Reports Medicine · January 2026

"NAD+ Restoration and BBB Integrity Repair Reverses Advanced Alzheimer's in Mice"

Journal: Cell Reports Medicine · Published: January 2026 · Model: 5xFAD (aggressive AD model)
Authors: Pieper Lab, Case Western Reserve / Harrington

DOI: 10.1016/j.xcrm.2025.102535

Note: AIXC provided computational support for this research, focusing on target identification and molecular docking validation.

Key Findings

Reversed amyloid plaque accumulation

Resolved tau neurofibrillary tangles

Repaired blood-brain barrier integrity

Restored cognitive function in vivo

Alzheimer's Clinical Genomics

2026 Research Highlights

Recent research advancing clinical intervention planning for Alzheimer's disease reversal.

Genomics & Foundation Models

Hierarchical Disease-State Generators for Neurodegenerative Genomics: A Clinical Benchmark for Intervention Modeling